IMMUNOBIOLOGY Noncanonical NF- B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
نویسندگان
چکیده
Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NFB signaling, as well as late expression of the antiinflammatory enzyme indoleamine 2,3dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NFB pathway using the NEMO-binding domain peptide or the noncanonical NFB pathway by small interfering RNA, we demonstrate that IDO expression requires noncanonical NFB signaling. Also, noncanonical NFB signaling down-regulates proinflammatory cytokine production in DCs. In addition, selective activation of the noncanonical NFB pathway results in noninflammatory DCs that suppress T-cell activation and promote the development of T cells with regulatory properties. These findings reveal an important role of the noncanonical NFB pathway in the regulation of immunity. (Blood. 2007;110:1540-1549)
منابع مشابه
Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.
Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-kappaB signaling, as well as late expression of the anti-inflammatory enzyme indoleamine 2,3-dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NF-kappaB pathway using the NEMO-binding domain peptide or the noncanonical NF-kappaB pathway by ...
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